ea0021p328 | Reproduction | SFEBES2009
Jayasena Channa N
, Nijher Gurjinder M K
, Abbara Ali
, Murphy Kevin G
, Lim Adrian
, Patel Daksha
, Mehta Amrish
, Todd Catriona
, Ramachandran Radha
, Donaldson Mandy
, Trew Geoffrey
, Ghatei Mohammad A
, Bloom Stephen R
, Dhillo Waljit S
Background: Hypothalamic amenorrhoea (HA) accounts for over 30% of cases of amenorrhoea in women of reproductive age. Current treatments have limited success rates and side effects. We have recently shown that a single injection of the novel hormone kisspeptin potently stimulates reproductive hormone release in women with HA. However, twice-daily kisspeptin administration to women with HA, results in tachyphylaxis due to desensitisation of the kisspeptin receptor. This suggest...